在马来西亚,真正耐药高血压在那些被转诊为不受控制的高血压患者中的流行:使用不同定义进行比较
John Jui Ping Yeo1, Leh Siang Yeo1, Shirley Siang Ning Tan1
1Clinical Research Center, Institute for Clinical Research, Sarawak General Hospital, Kuching, Malaysia.
概括
抗性高血压 (RH) 在亚洲成年人中常见,患有不受控制的高血压. 许多因高血压而转诊的患者需要进一步评估真正的RH,这突出了重大的公共卫生挑战.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 公共卫生 公共卫生
背景情况:
- 抗性高血压 (RH) 提出了重大的临床挑战,特别是在了解其定义和亚洲人口中的流行方面.
- 准确识别RH对于有效管理和减少心血管和并发症至关重要.
研究的目的:
- 确定真正耐药高血压 (RH) 在亚洲未控制高血压的初级保健中转诊的成年人中的患病率.
- 根据不同的国际指南,比较RH的流行率.
主要方法:
- 一项涉及成年人的横截面研究,涉及未经控制的高血压.
- 耐性高血压 (RH) 被定义为血压 (BP) 仍然高于值,尽管最佳治疗≥3种药物和生活方式的坚持,通过门诊血压监测评估.
- 使用马来西亚和2018年美国指南计算了患病率.
主要成果:
- 24.0% (马来西亚指导方针) 和63.7% (2018年美国指导方针) 的参考成年人符合真正的RH标准.
- 在26.6%的RH患者 (≥5种药物) 中发现了耐药性高血压.
- 患有RH的成年人比较年轻,更有可能是男性,BMI较高,并患有痛风,CKD和心痛等并发症.
结论:
- 在亚洲成年人中,高血压控制不良的高血压的患病率特别高.
- 很大一部分RH患者患有耐性高血压,这表明需要加强管理策略.
- 有针对性的干预措施至关重要,以减轻这一群体中大量的RH负担.
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