用于治疗糖尿病黄斑的levosulpiride:一个2期随机临床试验
Carlos D Núñez-Amaro1, Mariana López2, Elva Adán-Castro3
1Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro (UAQ), Querétaro, México.
Eye (London, England)
|September 6, 2023
概括
利沃苏比里德改善了糖尿病黄斑患者的视力和减少了胀. 这种治疗可能通过增加血管抑制素和降低VEGF和PlGF水平而带来好处.
科学领域:
- 眼科医生 眼科 眼科
- 糖尿病学 糖尿病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 糖尿病黄斑 (DME) 是糖尿病患者视力丧失的主要原因.
- 列沃苏尔皮里德是一种原动力学药物,已显示其在提高抗血管通透性和抗血管性质的药物 - - 血管抑制素 - - 的潜力.
- 之前的研究结果表明,瓦索因希宾可能有利于增殖性糖尿病视网膜病变 (PDR).
研究的目的:
- 调查levosulpiride在患有中心涉及糖尿病黄斑 (DME) 的患者中的生物活性和临床疗效.
- 评估levosulpiride对DME患者视力敏度,视网膜厚度和斑点体积的影响.
- 为了探索levosulpiride对血管内皮生长因子 (VEGF) 和胎盘生长因子 (PlGF) 在PDR患者的眼内水平的影响.
主要方法:
- 进行了一项前性,随机,双盲,双中心,第二阶段试验.
- 患有中心涉及的DME的患者接受了口服levosulpiride或安慰剂8周.
- 在手术前一周内,接受切除术的PDR患者接受了口服levosulpiride或安慰剂.
主要成果:
- 与安慰剂相比,8周后,levosulpiride显著改善了最佳校正的视力敏度,中央叶厚度 (CFT) 和平均黄斑体积 (MMV).
- 在接受levosulpiride治疗的患者中,更高比例的患者获得了显著的视觉效益和结构改善 (减少了CFT和MMV).
- 在PDR患者中,levosulpiride降低了VEGF和PlGF的玻璃体水平,没有报告显著的不良副作用.
结论:
- 服用口服levosulpiride 8 周后,该药物在改善DME中心患者的视觉和结构结果方面表现出有效性.
- 治疗效果可能由眼内血管抑制素的VEGF和PlGF上调和下调介导.
- 建议进行进一步的大规模临床试验,以评估levosulpiride在DME治疗中的长期疗效和安全性.
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