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相关概念视频

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

5.8K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.8K
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

18.9K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
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Karyotyping01:17

Karyotyping

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Overview
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相关实验视频

Updated: Jul 17, 2025

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
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Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

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分析多尺度3D基因组组织的计算方法.

Yang Zhang1, Lorenzo Boninsegna2, Muyu Yang1

  • 1Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA.

Nature reviews. Genetics
|September 6, 2023
PubMed
概括
此摘要是机器生成的。

新的计算工具分析基因组折叠和3D基因组组织,将结构与功能联系起来. 需要进一步整合基因组和成像数据,以了解3D基因组结构.

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3D Multicolor DNA FISH Tool to Study Nuclear Architecture in Human Primary Cells
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3D Multicolor DNA FISH Tool to Study Nuclear Architecture in Human Primary Cells

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Deciphering High-Resolution 3D Chromatin Organization via Capture Hi-C
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Deciphering High-Resolution 3D Chromatin Organization via Capture Hi-C

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相关实验视频

Last Updated: Jul 17, 2025

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
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Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

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3D Multicolor DNA FISH Tool to Study Nuclear Architecture in Human Primary Cells
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3D Multicolor DNA FISH Tool to Study Nuclear Architecture in Human Primary Cells

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Deciphering High-Resolution 3D Chromatin Organization via Capture Hi-C
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科学领域:

  • 基因组学就是基因组学.
  • 计算生物学 计算生物学
  • 分子生物学分子生物学

背景情况:

  • 全基因组映射和成像方面的进步揭示了基因组的空间组织.
  • 计算方法对于解释复杂的3D基因组数据至关重要.

研究的目的:

  • 讨论分析多尺度3D基因组组织的计算工具.
  • 探索基因组结构,特征和功能之间的联系.

主要方法:

  • 使用基于机器学习的方法.
  • 使用整合性结构建模框架.
  • 分析多尺度的三维 (3D) 基因组特征.

主要成果:

  • 在3D基因组组织,基因组/表观基因组特征和核组件之间进行系统的,多层次的连接划分.
  • 揭示了基因组结构和基因组功能之间的联系,包括转录.

结论:

  • 计算工具提高了对3D基因组组织和功能的理解.
  • 多样化的基因组和成像数据集的全面整合对于未来研究3D基因组结构在细胞表型中的功能作用至关重要.