在临床环境中使用Candida parapsilosis复合物
Miriam Govrins1, Cornelia Lass-Flörl2
1Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Nature reviews. Microbiology
|September 6, 2023
概括
坎迪达帕拉西洛斯复合体导致人类严重感染,特别是在婴儿中. 本综述详细介绍了其流行病学,诊断,耐药性和临床医生新兴的治疗策略.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 坎迪达 (Candida) 护症复合体是导致候选血症和其他感染的主要原因,特别是在早产婴儿中.
- 这种复杂性包括C. parapsilosis,C. orthopsilosis和C. metapsilosis,呈现出不同的临床表现.
- 高埃奇诺坎丁MIC和新兴的弗卢可纳抗性是显著的临床问题.
研究的目的:
- 提供最新的流行病学,诊断,耐药性模式和Candida parapsilosis综合体的治疗审查.
- 以微生物学和临床特征来比较该综合体内的三个物种.
- 为临床医生和研究人员提供关于Candida物种感染的资源.
主要方法:
- 关于Candida parapsilosis复合体的最新医学数据的文献综述.
- 对三种姐妹物种的临床和微生物特征进行比较分析.
- 综合有关诊断,耐药性和治疗选择的当前知识.
主要成果:
- 坎迪达帕拉西洛斯复合体表现出独特的耐药机制,包括影响类素敏感性的FKS1多态.
- 越来越多地报告了抗真菌耐药性的克隆性疫情,特别是对可纳的耐药性.
- 临床表现范围从殖民到严重的传播感染,新生儿重症监护病房的负担很高.
结论:
- 由于抗真菌耐药性和其在脆弱人群中的流行,Candida parapsilosis复合体构成了越来越大的挑战.
- 了解特定物种的特征对于有效的诊断和管理至关重要.
- 弥合翻译知识差距对于应对未来的治疗挑战至关重要.
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