在高血压与正常血压怀孕2年后的儿童生长结果:一项P4研究
Megan L Gow1,2,3, Priya Vakil4, Lynne Roberts5,6
1Discipline of Paediatrics and Child Health, School of Clinical Medicine, UNSW Medicine and Health, Sydney, NSW, Australia. megan.gow@sydney.edu.au.
Pediatric research
|September 6, 2023
概括
暴露于高血压妊娠障碍的婴儿,如先兆子 (PE) 和妊娠高血压 (GH),从出生到2岁时体重增加加速. 这种快速增长可能会增加未来心脏代谢疾病的风险.
科学领域:
- 产周医学 产周医学
- 儿科生长和发展的发展.
- 孕产妇和胎儿的医学
背景情况:
- 妊娠的高血压疾病,包括妊娠高血压 (GH) 和孕前 (PE),可能会影响婴儿的发育.
- 宫内暴露可能会对孩子的长期健康产生影响.
研究的目的:
- 为了比较婴儿从出生到2岁的成长结果,在那些暴露于正常压力妊娠 (NTP),GH或PE的婴儿中.
- 为了确定高血压妊娠障碍对婴儿生长轨迹的潜在长期影响.
主要方法:
- 前性队列研究 (P4) 涉及来自NTP (n=240),GH (n=19) 或PE (n=66) 的母亲的婴儿.
- 使用出生,6个月和2年的体重z-score,体重z-score的变化,快速体重增加和条件体重增加来评估婴儿的成长.
- 在6个月和2年的评估中应用了年龄校正.
主要成果:
- 与NTP或GH组相比,暴露于PE的婴儿的出生体重和长度z-score明显较低.
- 在6个月或2年后,两组之间没有观察到生长结果的显著差异.
- 与NTP婴儿相比,暴露于GH和PE的婴儿在z-score上显著增加体重和从出生到2岁的快速体重增加.
- 经过对混因素进行调整后,暴露于PE的婴儿的加速体重增加仍然显著.
结论:
- 孕期高血压和妊娠前与婴儿体重增加加快有关,直到2岁.
- 这种加速生长的轨迹可能会增加未来心脏代谢疾病的风险.
- 建议在暴露于妊娠高血压疾病后监测婴儿生长模式,以减轻肥胖和相关疾病的风险.
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