在炎症性关节炎中天生的免疫记忆
Maxime M Jeljeli1, Iannis E Adamopoulos2
1Department of Rheumatology and Clinical Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Nature reviews. Rheumatology
|September 6, 2023
概括
天生的免疫细胞可以发展记忆,这一过程被称为训练免疫,影响慢性炎症和自身免疫性疾病,如炎症性关节炎. 这种细胞重编程有助于疾病爆发和骨破坏.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 类风湿病学 类风湿病学
背景情况:
- 免疫性记忆,传统上与适应性T细胞和B细胞有关,具有可以追溯到古老观察病原体保护的历史先例.
- 最近的研究表明,天生的免疫细胞也具有类似记忆的特性,这种现象被称为"训练免疫力".
- 训练有素的免疫正在重塑对慢性炎症和自身免疫性疾病的理解.
研究的目的:
- 在炎症性关节炎的背景下,审查先天性免疫细胞的类似记忆的特征.
- 探索慢性炎症环境和疾病发病过程中的细胞重编程之间的相互作用.
主要方法:
- 关于先天免疫记忆和炎症性关节炎的当前文献的综述.
- 分析涉及细胞因子信号传递,新陈代谢和表观遗传重编程的机制.
- 检查成熟的先天细胞 (包括骨质细胞) 中的印记记忆.
主要成果:
- 异常的促炎信号驱动了血液构造原始体的代谢和表观遗传重编程,恶化了炎症反应和骨质细胞分化.
- 这种重编程导致炎症性关节炎中骨破坏加剧.
- 记忆印在成熟的细胞上,如骨质细胞,会影响治疗反应和疾病的结果,导致持续的爆发和复发.
结论:
- 天生的免疫记忆在炎症性关节炎的发病过程中起着重要作用.
- 慢性炎症的细胞重编程有助于疾病的进展,骨质损失和治疗耐药性.
- 了解先天细胞中训练有素的免疫力为治疗慢性炎症和自身免疫性疾病提供了新的视角.
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