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在瘤驱动的免疫抑制中需要中性粒细胞的CD300ld

Chaoxiong Wang1,2, Xichen Zheng1, Jinlan Zhang3

  • 1Institute of Pediatrics of Children's Hospital of Fudan University, the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.

Nature
|September 6, 2023
PubMed
概括

研究人员确定了CD300ld,该分子在多态核髓原抑制细胞 (PMN-MDSC) 上,是瘤免疫抑制的关键驱动因素. 向CD300ld可以通过逆转抑制瘤微环境来增强癌症免疫疗法.

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Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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