非侵入性胚胎活力测试与常规试管婴儿对IVF/ICSI患者活产率的影响:双盲,多中心,随机对照试验的研究方案
Yan-Fei Cheng1,2, Cui-Lian Zhang3, Yun Liu4
1Shenzhen Key Laboratory of Fertility Regulation, Reproductive Medicine Center, The University of Hong Kong-Shenzhen Hospital, No. 1 Haiyuan Road, Shenzhen, 518053, Guangdong, China.
BMC pregnancy and childbirth
|September 6, 2023
概括
非侵入性胚胎活力测试 (niEVT) 可能为传统试管婴儿提供一种替代方案,有可能提高活产率并减少流产. 这项研究将初次胚胎移植的妇女的niEVT与试管婴儿进行比较.
科学领域:
- 生殖医学 生殖医学
- 胚胎学 胚胎学
- 遗传学 是一个遗传学.
背景情况:
- 预植入前遗传测试 (PGT-A) 改善了结果,但需要胚胎活检.
- 使用已耗尽的胚芽细胞培养基的非侵入性PGT-A (niPGT-A) 显示出有前途.
- 有关PGT-A对胚胎发育和儿童健康的影响存在担忧.
研究的目的:
- 确定非侵入性胚胎活力测试 (niEVT) 是否为首次胚胎移植提供比传统试管婴儿更好的临床结果.
- 调查niEVT是否能提高晚产妇年龄 (AMA) 和不同受精协议 (IVF/ICSI) 中的活产率.
主要方法:
- 这是一项双盲多中心随机对照试验 (RCT),涉及1140名年龄在20-43岁之间的患者.
- 患者将至少有两个优质的胚胎囊.
- 主要结局:第一个胚胎移植的活产率;次要结局:临床怀孕,正在进行的怀孕,流产,累积活产率,宫外怀孕和怀孕的时间.
主要成果:
- 本节不适用,因为该研究正在进行中.
结论:
- 这项试验将niEVT与传统试管婴儿进行比较,以评估对怀孕,流产和活产率的影响.
- 该研究将探讨基于患者年龄和受精方法 (IVF/ICSI) 的临床结果差异.
- 将提供关于niEVT对第一个胚胎移植结果临床影响的证据.
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