对预测系统性瘤治疗对重病住院患者的益处的因素的评估:一项回顾性研究
Milena Brachmans Mascarenhas Neves1,2, Yuri Costa Sarno Neves3, Juliana Vieira Biason Bomonetto4
1Centro Universitário Faculdade de Medicina do ABC (FMABC), Santo André, SP, Brazil. milenabrachmans@gmail.com.
BMC palliative care
|September 6, 2023
概括
对于末期癌症患者,血清白蛋白水平预测了紧急化疗的生存益处. 较低的白蛋白表明早期死亡风险更高,有助于重病患者的治疗决策.
科学领域:
- 在瘤学瘤学.
- 临床医学 临床医学
- 癌症研究 癌症研究
背景情况:
- 末期癌症患者的表现状况不佳,会带来复杂的临床挑战.
- 由于临床条件,瘤紧急情况和转移性疾病,死亡风险高.
- 在确定这种人群中化疗益处的预测因素方面存在研究缺口.
研究的目的:
- 确定预测严重癌症患者住院期间紧急化疗的益处的因素.
- 解决在癌症息护理中需要更好的决策工具的需求.
主要方法:
- 一个主要的癌症中心的回顾性观察研究.
- 纳入标准:年龄≥18岁,ECOG-PS得分≥2,接受非选择性化疗的患者.
- 从医疗记录 (2019-2020) 中收集的数据,重点关注化疗后的生存率.
主要成果:
- 对89名患者病历的分析显示,较差的结局 (30天内死亡) 与较高的ECOG-PS,剂量减少,较低的白蛋白/血红蛋白/肌素清除,以及较高的白细胞/中性粒细胞/胆红素/尿素/CRP之间的关联.
- 多变量分析发现血清白蛋白是唯一具有统计意义的预测因子 (HR=0.35,CI:0.14-0.90,p=0.034).
结论:
- 血清白蛋白水平,以及其他临床和实验室标志物,可以预测晚期癌症患者的化学治疗后早期死亡率.
- 这些发现可以为接受紧急化疗的危急癌症患者的治疗决策提供信息.
- 这项研究有助于了解入院,重病癌症患者积极化疗对益处的预测因素.
关键词:
化疗 化疗是一种化学疗法.在 ECOG 中,你会发现 ECOG 的作用.生命的终结 生命的终结医院医药 医院医药 医院医药抚慰性护理是一项非常重要的护理.患有癌症的患者.系统性瘤治疗 系统性瘤治疗更多相关视频
04:04Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
10.5K
08:12Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
Published on: March 14, 2019
5.5K
相关概念视频
01:21Cancer Survival Analysis
381
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
381
02:49Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
02:56Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
01:20Comparing the Survival Analysis of Two or More Groups
220
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
220