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在瘤微环境和癌症预后中应用基于放射学的多种组合

Wendi Kang¹, Xiang Qiu², Yingen Luo¹

¹Department of Interventional Therapy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Panjiayuan Nanli 17# Chaoyang District, Beijing, 100021, China.

Journal of translational medicine

|September 6, 2023

概括

整合放射学,病理学,基因组学和转录学,可以全面了解瘤微环境 (TME). 这种多组学方法提高了癌症预后预测,并解码了TME异质性.

科学领域:

在瘤学瘤学.
医疗成像医学成像
生物信息学是一种生物信息学.

背景情况:

瘤微环境 (TME) 对癌症的进展和治疗反应至关重要.
免疫疗法强调了理解TME的重要性.
放射学和病理学为瘤提供了基于成像的先进洞察力.

研究的目的:

审查放射性生物标志物在预测TME特征中的作用.
探索放射学与基因组学,转录组学和病理组学 (多组学) 的整合.
评估多组学在解码TME异质性和预测癌症预后方面的应用.

主要方法:

对用于TME评估的放射性生物标志物的当前研究进行审查.
分析放射学,基因组学,转录学和病理学之间的相互作用.
讨论TME特征和预后预测的多组学策略.

主要成果:

放射学,病理学,基因组学和转录学协同解码TME异质性.
综合的多组学分析改善了癌症预后的预测.
图像和遗传数据的整合彻底改变了"数字活检"的概念.

结论:

多组学方法,特别是将放射学与其他"组学"数据集成,对于全面的TME评估至关重要.
这种协同分析对推进癌症预后评估具有重大前景.
未来的研究应该专注于克服挑战,并利用TME研究的多经济领域的机遇.

关键词:

生物标志物生物标志物癌症预后癌症预后多种omics组合的组合.无线电学 (Radiomics) 是一种无线电学.瘤微环境是一个微环境.

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The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...