对过氧化的重复暴露是否会诱导Candida auris的耐药性?
Luis Cobrado1,2,3, Elisabete Ricardo4,5, Patricia Ramalho4,5
1Division of Microbiology, Department of Pathology, Faculty of Medicine, University of Porto, Al. Prof. Hernâni Monteiro, Porto, 4200 - 319, Portugal. lcobrado@med.up.pt.
Antimicrobial resistance and infection control
|September 6, 2023
概括
对过氧化 (H2O2) 的重复暴露没有诱导Candida auris.的耐药性. 这项研究证实了H2O2的存在.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 与医疗保健相关的感染 (HAI) 是一个重大问题.
- 过氧化 (H2O2) 是一种已知的生物杀伤剂,但其对白 Candida auris 的有效性和诱导抗性的潜力需要进一步研究.
- 黄是一种新兴的酵母菌,在医疗保健环境中构成挑战.
研究的目的:
- 为了评估30天暴露于过氧化 (H2O2) 后的Candida auris耐药性的诱导.
- 为了比较H2O2对Candida auris与其他Candida物种的疗效.
- 为了确定不同菌株的C. auris是否表现出对H2O2.2.的不同敏感性.
主要方法:
- 对Candida auris,Candida albicans和Candida parapsilosis的类型菌株和临床分离物多次暴露于H2O230天.
- 评估最小抑制度 (MIC) 值以检测电阻诱导.
- 在不同的Candida物种和C. auris菌株中比较H2O2疗效.
主要成果:
- 在诱导菌株和对照菌株之间没有观察到H2O2最小抑制度 (MIC) 值的显著差异.
- 过氧化对所有测试的Candida物种表现出类似的有效性.
- 在Candida auris.的不同菌株之间没有发现对H2O2敏感性的差异.
结论:
- 过氧化 (H2O2) 似乎不会在重复暴露时诱导Candida auris的耐药性.
- H2O2对各种Candida物种有效,包括C. auris.
- 建议采用H2O2用于对C. auris的消毒方案,以提高患者的安全性和降低医疗保健成本.
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