自主嗅觉粘膜中介细胞干细胞治疗改善了慢性耐火性的神经网络
相关实验视频
Updated: Jul 28, 2026
09:19
Isolating Nasal Olfactory Stem Cells from Rodents or Humans
Published on: August 22, 2011
30.8K
Zheng-Zhao Liu1,2,3,4,5,6, Yan Huang7,8,9,10, Chun-Gu Hong2
1Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Stem cell research & therapy
|September 6, 2023
概括
嗅觉粘膜介质干细胞 (OM-MSCs) 在治疗耐药性方面表现有前途. 这种疗法改善了控制,认知功能,并减少了患者和动物模型中的大脑缩.
科学领域:
- 神经科学是一个神经科学.
- 再生医学是一种再生医学.
- 免疫学 免疫学 免疫学
背景情况:
- 耐药性,或耐药性,存在重大治疗挑战.
- 嗅觉粘膜介质干细胞 (OM-MSCs) 是干细胞治疗的安全和可访问的来源.
- 调查OM-MSC作为耐火性的潜在治疗方法至关重要.
研究的目的:
- 评估自主OM-MSCs在治疗耐火性患者中的疗效.
- 在已建立的性小鼠模型中探索OM-MSCs的治疗机制.
- 评估OM-MSC治疗的长期安全性和益处.
主要方法:
- OM-MSCs被隔离和表征;自主治疗被输入肠道.
- 使用斯科波胺和皮洛卡尔诱导了一种性小鼠模型,随后进行了OM-MSCs的立体毒性微注射.
- 评估了活动,脑结构 (MRI),神经和Treg细胞透,细胞因子水平,认知功能和运动技能.
主要成果:
- 八年后的随访显示,控制,认知功能显著改善,患者没有任何不良影响.
- 在接受治疗的患者中,MRI揭示了大脑缩的缓解.
- 在小鼠中,OM-MSC治疗促进了Treg细胞的招募,减少了神经炎症,增强了神经网络的修复,改善了认知和运动功能.
结论:
- 自主OM-MSC治疗在治疗慢性耐火性方面表现出有效性.
- OM-MSCs代表了未来治疗策略的有希望的治疗候选者.
- 这项研究提供了证据证明OM-MSCs在神经恢复和的免疫调节方面的潜力.
更多相关视频
10:33Transplantation of Olfactory Ensheathing Cells to Evaluate Functional Recovery after Peripheral Nerve Injury
Published on: February 23, 2014
11.8K
08:33Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders
Published on: December 4, 2014
9.8K
相关概念视频
01:37Neural Regulation
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
01:19Ligand-gated Ion Channels
Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that include the...
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that include the...