在韩国儿童中首次检测到D68肠道病毒,2022年9月
Ki Wook Yun1,2, Bin Ahn1,2, Sung Hwan Choi2
1Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
Infection & chemotherapy
|September 7, 2023
概括
肠道病毒D68 (EV-D68) 首次在韩国儿童中被检测到,这些儿童患有呼吸道感染. 在韩国,EV-D68的患病率和严重程度似乎低于其他国家.
科学领域:
- 病毒学 病毒学
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
背景情况:
- 肠道病毒D68 (EV-D68) 是一种重新出现的病毒病原体,引起呼吸系统疾病和急性软性脑膜炎,特别是在儿童中.
- 在韩国以前没有报告过EV-D68.
- 这项研究旨在检测有呼吸道感染的韩国儿童的EV-D68.
研究的目的:
- 在韩国儿童的鼻吸管中识别D68型肠道病毒 (EV-D68) 的存在.
- 为了描述检测到的EV-D68菌株的遗传和家族遗传特征.
- 评估EV-D68在韩国儿科人口中的循环和潜在影响.
主要方法:
- 商业和内部多重复合逆转录PCR (mRT-PCR) 套件用于EV-D68检测的评估.
- 从2022年开始,对儿童呼吸道感染的样本进行选择,这些样本对人鼻病毒 (HRV) 和/或肠道病毒 (EV) 呈阳性.
- RNA提取,部分5'-UTR和VP1基因放大,测序和EV-D68菌株的遗传学分析.
主要成果:
- 与商业套件相比,公司内部的mRT-PCR套件展示了优越的EV-D68检测能力.
- 在2022年晚些时候,在患有发烧和/或呼吸道症状的住院儿童中发现了三种EV-D68菌株.
- 遗传学分析将确定的韩国EV-D68菌株置于B3亚群内,显示出与欧洲菌株更为密切的遗传关系.
结论:
- 这项研究报告了在韩国儿童中首次检测到EV-D68,通过对其他肠道病毒呈阳性样本的mRT-PCR分析确定.
- 在2022年秋季,EV-D68在韩国流通.
- 与国际报告相比,在韩国观察到的EV-D68的流行率和严重程度似乎不那么明显.
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