在有机介质中合成的β-三酸用于控制释放的药物输送应用在生物支架中
Md Sahadat Hossain1, Md Aftab Ali Shaikh1,2, Md Najem Uddin3
1Institute of Glass & Ceramic Research and Testing, Bangladesh Council of Scientific and Industrial Research (BCSIR) Dhaka 1205 Bangladesh shanta_samina@yahoo.com aftabshaikh@du.ac.bd.
RSC advances
|September 7, 2023
概括
这项研究合成了β-三酸 (β-TCP) 支架,将它们装载在西普罗夫洛克萨上,并评估了它们的药物释放和抗菌特性. 药物装载的支架显示出对常见病原体具有显著的抗菌活性.
科学领域:
- 生物材料科学 生物材料科学
- 材料化学 材料化学
- 纳米技术纳米技术
背景情况:
- β-三酸 (β-TCP) 是一种广泛研究的生物陶,在骨组织工程中具有应用.
- 开发具有可控性质的单相β-TCP对于优化其在生物医学应用中的性能至关重要.
- 研究β-TCP支架的药物传递和抗菌能力可以提高它们的治疗潜力.
研究的目的:
- 在有机介质中合成单相β-TCP.
- 描述合成的β-TCP及其衍生的支架.
- 评估来自β-TCP支架的西普洛素的药物加载和释放概况.
- 评估开发的支架的抗菌活性和生物活性.
主要方法:
- 单相β-TCP是用碳酸和酸在乙中合成的.
- 使用XRD,FTIR,FESEM,VSM和UV-Vis-NIR光谱法进行表征.
- 通过在900°C下压缩和烧结β-TCP粉末制造的脚手架.
- 药物加载和释放研究与28天的西普罗夫洛克萨.
- 细胞毒性,血液溶解,抗菌检测,以及SBF浸泡用于生物活性评估.
主要成果:
- 成功合成了单相β-TCP.
- 鉴定证实了材料的性能.
- β-TCP支架载有2.87%的西普洛素,在28天内释放了37%.
- 药物装载的支架表现出对大肠杆菌,S. typhi和S. aureus的增强抗菌活性,具有显著的抑制区.
- 药物释放的支架显示出抗微生物活性,即使是针对格拉姆阴性细菌,与粉末形式不同.
结论:
- 合成的β-TCP适用于开发药物输送支架.
- β-TCP支架表明有效的西普罗夫洛克萨辛加载和持续释放.
- 开发的支架具有显著的抗微生物特性和生物医学应用的潜力.
- 该研究强调了β-TCP支架作为有效的抗菌剂和药物输送系统的潜力.
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