通过三组分反应,选择性地构建了dspiro[indoline-3,2'-quinoline-3',3''-indoline]和dspiro[indoline-3,2'-pyrrole-3',3''-indoline]通过三组分反应
Ziying Xiao1, Fengshun Xu1, Jing Sun1
1College of Chemistry & Chemical Engineering, Yangzhou University, Jiangsu, Yangzhou 225002, China.
Beilstein journal of organic chemistry
|September 7, 2023
概括
研究人员开发了一种新方法,利用三组分反应合成新型的dsipirooxindole化合物. 这种高效的工艺产生了具有高选择性的复杂的螺旋氧indole衍生物.
科学领域:
- 有机化学 有机化学
- 合成化学 合成化学
背景情况:
- 螺旋氧醇是一种具有显著生物活性的异环化合物.
- 开发高效的合成路径,用于新型的螺旋二醇支架,对于药物化学至关重要.
研究的目的:
- 开发一种方便和高效的合成程序,用于新型的dsipiroxindole图案.
- 为了探索多功能型的diso[indoline-3,2'-quinoline-3',3''-indoline]和diso[indoline-3,2'-pyrrole-3',3''-indoline]衍生物的合成. 为了探索多功能化的diso[indoline-3,2'-quinoline-3',3''-indoline]和diso[indoline-3,2'-pyrrole-3',3''-indoline]衍生物的合成.
主要方法:
- 氨基酸,伊萨和在位生成的3-伊萨-1,4-二碳化合物的基质促进的三组分反应.
- 皮皮瑞丁促进的三组分反应涉及氨基酸,伊萨和3 - 乙氧化碳甲基氧或3 - 基基氧的二米添加物.
主要成果:
- 成功地构建了新的dsipiroxindole图案.
- 合成多功能型的迪斯皮罗[印-3,2'-金-3',3''-印]衍生物,产量好,二选择性高.
- 形成独特的diso[indoline-3,2'-pyrrole-3',3''-indoline]衍生物与一个循环二替代剂.
结论:
- 已经建立了一个多功能且方便的合成策略,用于多种类型的spirooxindole架构.
- 拟议的反应机制提供了对不同螺旋氧化产物的形成的洞察力.
- 这种方法提供了一个有价值的工具,用于访问复杂的螺旋氧醇支架进行进一步的研究.
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