儿童注意力缺陷/多动症的扩散量微观结构异常:一个AFQ和TBSS研究
Rui Hu1,2, Fan Tan3, Wen Chen2
1Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Frontiers in psychiatry
|September 7, 2023
概括
这项研究在患有注意力缺陷/多动症 (ADHD) 的儿童的右带皮带中发现了特定的白质异常. 自动纤维量化 (AFQ) 在检测这些差异方面比TBSS更为敏感,突出显示了右带束在ADHD中的作用.
科学领域:
- 神经成像是一种神经成像.
- 发育神经科学的发展神经科学.
- 儿科神经学 儿科神经学
背景情况:
- 注意缺陷/多动障碍 (ADHD) 是一种常见的神经发育障碍.
- 以前的研究表明,在ADHD中,白质微观结构发生变化,但这些发现是不一致的.
- 了解这些变化对于诊断和治疗儿童ADHD至关重要.
研究的目的:
- 通过自动化纤维量化 (AFQ) 和基于通道的空间统计 (TBSS) 来研究ADHD儿童的白质微观结构差异.
- 分析白质异常与ADHD执行功能障碍之间的相关性.
- 为了比较AFQ和TBSS在检测ADHD白质变化的灵敏度.
主要方法:
- 前性研究包括27名患有ADHD的儿童和22名健康对照人群 (HC).
- 进行了扩散曲解成像 (DKI) 和扩散张力成像 (DTI).
- AFQ和TBSS用于分析白质完整性,计算诸如轴向扩散率 (AD) 和平均扩散率 (MD) 等参数. 执行职能使用行为评级库存执行职能 (BRIEF) 测试进行评估.
主要成果:
- 与HC患者相比,ADHD患者在BRIEF测试中表现较差.
- 与HC相比,AFQ分析显示,在ADHD患者的右环膜束 (CB_R) 中,平均AD显著更高.
- 在TBSS分析中,没有发现群体之间的DKI或DTI参数有显著差异. 在白质扩散参数和执行功能得分之间没有发现显著的相关性.
结论:
- 自动纤维量化 (AFQ) 是一种敏感的方法,用于检测ADHD的焦点白质异常,特别是在右环膜束 (CB_R).
- 右环膜束似乎在与ADHD相关的白质变化中发挥着关键作用.
- 这些发现有助于更好地了解焦点白质异常和ADHD之间的关系.
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