非洲人群中长期COVID的负担,原因和特点:快速系统审查
Peter S Nyasulu1,2, Jacques L Tamuzi1, Rajiv T Erasmus3
1Division of Epidemiology & Biostatistics, Department of Global Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
IJID regions
|September 7, 2023
概括
长期COVID影响了非洲41%的先前感染的个体,疲劳和呼吸困难是常见的. 凝血过高和血栓形成可能会使这种人群的并发症恶化.
科学领域:
- 全球健康 全球健康
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 长期COVID是SARS-CoV-2感染的后急性后果,对全球健康构成了重大挑战.
- 了解其在非洲等不同人口中的流行率和特征对于有针对性的干预至关重要.
研究的目的:
- 为了确定非洲人口中长期COVID的流行率.
- 识别最常见的症状,相关的并发症和潜在的病理生理机制.
- 将发现与全球长期COVID数据进行比较.
主要方法:
- 关于非洲人口长期COVID的研究的系统审查和叙事综合.
- 使用随机效应模型计算的聚合流行率.
- 包括来自七个非洲国家的14项研究,包括6030名感染SARS-CoV-2的参与者.
主要成果:
- 在非洲人群中观察到长期COVID的总流行率为41% (95%CI:26-56%).
- 最常见的症状包括疲劳 (41%),呼吸障碍 (25%) 和认知障碍 (40%).
- 相关因素包括晚年,女性性别,急性阶段症状,COVID-19严重程度,肥胖,高血压,糖尿病和慢性疾病.
结论:
- 非洲的长期COVID患病率与全球估计相当,症状负担可能更高.
- 高凝血和血小板缺乏的血粘度与病理生理学有关.
- 非洲人群的并发症可能会加剧长期COVID并发症,因为高凝血和血栓形成的风险增加.
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