Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Bias in Epidemiological Studies01:29

Bias in Epidemiological Studies

343
Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:  
343
Confounding in Epidemiological Studies01:27

Confounding in Epidemiological Studies

188
Confounding in statistical epidemiology represents a pivotal challenge, referring to the distortion in the perceived relationship between an exposure and an outcome due to the presence of a third variable, known as a confounder. This variable is associated with both the exposure and the outcome but is not a direct link in their causal chain. Its presence can lead to erroneous interpretations of the exposure's effect, either exaggerating or underestimating the true association. This...
188
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

403
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
403
Human Genetics01:28

Human Genetics

610
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
610
Randomized Experiments01:13

Randomized Experiments

7.0K
The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
7.0K
Longitudinal Studies01:26

Longitudinal Studies

186
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
186

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Handgrip strength and risk of common infections and sepsis: Two prospective cohorts with proteomic mediation analysis.

Archives of gerontology and geriatrics·2026
Same author

Proxied therapeutic inhibition on sclerostin and atrial fibrillation risk.

Communications medicine·2026
Same author

Application of age- and sex-specific reference intervals for thyroid-stimulating hormone and free thyroxine in evaluating incidence and trends of thyroid dysfunctions: A population-based cohort study.

BMC medicine·2026
Same author

Population-scale genomic medicine with the Hong Kong Genome Project.

Nature medicine·2026
Same author

Asia-Pacific consensus statement on medication-related osteonecrosis of the jaw in patients with osteoporosis.

Osteoporosis and sarcopenia·2026
Same author

Association Between Calcium Supplementation and Recurrence of Cardiovascular Events in Patients With Cardiovascular Disease: A Population-Based Cohort Study.

Journal of the American Heart Association·2026

相关实验视频

Updated: Jul 17, 2025

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.6K

COVID-19和认知表现:孟德尔的随机化研究

Ching-Man Tang1, Gloria Hoi-Yee Li1, Ching-Lung Cheung2

  • 1Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, China.

Frontiers in public health
|September 7, 2023
PubMed
概括
此摘要是机器生成的。

对SARS-CoV-2感染的遗传责任可能会导致认知障碍,可能由系统性炎症介导. 建议对后COVID认知缺陷的抗炎治疗进行进一步的研究.

关键词:
在 COVID-19 疫情中,门德尔的随机化这是一种SARS-CoV-2感染.认知表现 认知表现 认知表现炎症标志物 炎症标志物

更多相关视频

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
09:38

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

15.0K
Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
06:58

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

7.4K

相关实验视频

Last Updated: Jul 17, 2025

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.6K
Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
09:38

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

15.0K
Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
06:58

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

7.4K

科学领域:

  • 神经科学是一个神经科学.
  • 遗传学 是一个遗传学.
  • 免疫学 免疫学 免疫学

背景情况:

  • 认知障碍是COVID-19后的一个常见症状.
  • 需要调查SARS-CoV-2感染和认知缺陷之间的因果关系.

研究的目的:

  • 为了确定对SARS-CoV-2感染或严重的COVID-19的遗传责任是否导致认知缺陷.
  • 探索系统性炎症在这种因果途径中的作用.

主要方法:

  • 使用单变量和多变量门德尔随机化 (MR) 分析.
  • 评估了SARS-CoV-2感染,住院和严重疾病的遗传责任.
  • 在多变量MR中调整了五种炎症标志物 (CRP,IL-1β,IL-6,IL-8,TNF-α)

主要成果:

  • 宿主对SARS-CoV-2感染的遗传责任与较低的认知表现相关 (IVW: -0.023,95% CI: -0.038至 -0.009).
  • 这种关联在调整炎症标志物时减弱了 (IVW: -0.022,95% CI: -0.049至0.004).
  • 对于住院或严重COVID-19的遗传责任与认知表现没有发现显著的关联.

结论:

  • 系统性炎症可能会调解SARS-CoV-2感染对认知能力下降的遗传责任的因果作用.
  • 对COVID-19幸存者的认知障碍抗炎药物的进一步研究是有必要的.