短期的食纤维干预在研究中产生一致的肠道微生物群反应
Cynthia I Rodriguez1, Kazuo Isobe2, Jennifer B H Martiny1
1University of California, Irvine.
Research square
|September 7, 2023
概括
食纤维摄入量始终影响人类肠道微生物群,尽管存在个体差异. 这项对21项研究的分析揭示了细菌对增加纤维消费的反应.
科学领域:
- 微生物组研究的研究.
- 人类肠道微生物组
- 饮食干预措施 饮食干预措施
背景情况:
- 人的肠道微生物组组成在个体之间有很大差异.
- 食纤维对肠道健康至关重要,但其对微生物群的影响报告不一致.
- 个体间的变化和干预细节有助于研究结果的不同.
研究的目的:
- 在健康个体的肠道微生物群中识别一致的纤维诱导反应.
- 重新分析来自多项食纤维干预研究的16S rRNA测序数据.
- 通过合成数据来克服个别研究变异性的局限性.
主要方法:
- 重新分析了16S rRNA测序数据.
- 包括12项人类研究中的21种食纤维干预措施.
- 分析了来自538名受试者的2564个便样本.
主要成果:
- 短期纤维的增加在研究中引起了一致的肠道微生物群反应.
- 纤维摄入量解释了1.5%的组成变化,而个体变化占82%.
- 阿尔法多样性下降,特定的细菌种群在相对丰度上表现出保守的变化.
结论:
- 合成和重新分析微生物组数据对于确定一致的反应具有强大作用.
- 饮食纤维干预导致肠道微生物群的持续变化,尽管个体间的差异很大.
- 特定的细菌种群对增加的纤维摄入量始终有反应.
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