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根据生物信息学和实验分析,确定CCDC115作为肝癌的不良预后生物标志物

Chang Su^1,2, Jing-Cheng Yang¹, Zheng Rong¹

¹Precision Pharmacy & Drug Development Center, Department of Pharmacy, Tangdu Hospital, Air Force Military Medical University, Xi'an, China.

|September 7, 2023

概括

卷曲卷曲域含有蛋白115 (CCDC115) 在肝肝细胞癌 (LIHC) 中被上调,并与预后不佳有关. 准CCDC115可能会提高LIHC治疗疗效.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
癌症研究癌症研究

背景情况:

肝肝细胞癌 (LIHC) 由于高发病率和晚期检测,存在诊断挑战.
卷曲卷曲域含蛋白115 (CCDC115),一个真空ATPase组件,在癌症中显示出改变的表达,但其LIHC作用尚不清楚.

研究的目的:

调查CCDC115在LIHC中的功能作用和预后意义.
探索CCDC115与LIHC中的癌症途径和免疫标记物的关联.

主要方法:

对LIHC患者数据库分析CCDC115表达和与预后的相关性.
在体外实验中评估CCDC115对肝癌细胞行为和PI3K-Akt通路蛋白的影响.

主要成果:

在LIHC瘤组织中,CCDC115的表达显著升高,与较差的患者结局相关.
CCDC115的表达与PI3K-Akt路径,人类白细胞抗原分子和免疫检查点分子有关.
CCDC115影响肝癌细胞增殖,转移,索拉芬尼布耐药性和PI3K-Akt通路蛋白质表达.

结论:

CCDC115作为LIHC的潜在诊断和预后生物标志物.
准CCDC115提供了一个有前途的治疗策略,以提高肝癌治疗的有效性.

关键词:

美国疾病预防控制中心115 药物耐药性药物耐药性药物耐药性肝细胞癌是肝细胞癌.通过PI3K-Akt路径.预测预后预测预测

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