身体组成参数与克罗恩病患者内镜严重程度相关,这些患者接受了因弗力西马布治疗
Frontiers in nutrition
|September 7, 2023
概括
身体组成的变化在克罗恩病 (CD) 中很常见. 骨肌肉质量指数 (SMI) 是一种可靠的疾病活动指标,用于治疗因弗利西马布 (IFX) 的CD患者,与内镜严重程度相关.
科学领域:
- 胃肠病学 胃肠病学
- 放射学 放射学是一门学科.
- 营养科学 营养科学
背景情况:
- 克罗恩氏病 (CD) 的特点是疾病活动和行为变化.
- 在CD患者中经常观察到身体组成的变化,这可能反映了疾病的严重程度.
研究的目的:
- 为了研究在接受因弗利西马布 (IFX) 治疗的CD患者中身体组成参数和疾病严重程度之间的关系.
- 在确定CD活动状态时,评估身体组成参数的诊断价值.
主要方法:
- 用IFX治疗的CD患者的回顾性分析,通过L3脊椎水平的CT扫描来评估身体成分.
- 身体成分指数 (SAI,VAI,SMI) 与疾病活动 (SES-CD) 和行为之间的相关性分析.
- 接收器操作特征 (ROC) 曲线分析,以评估相关参数的诊断性能.
主要成果:
- 在不同的疾病活动水平中,在皮下脂肪指数 (SAI),内脏脂肪指数 (VAI) 和骨肌量指数 (SMI) 中发现了显著差异.
- SAI,VAI和SMI被确定为疾病活动状态的独立相关物.
- 在中度至重度的疾病活动中,SMI表现出最高的诊断准确性 (AUC=0.865).
- SAI,SMI和骨肌肉质量下降在疾病行为组之间存在差异,但不是独立的相关性.
结论:
- 在IFX治疗的CD患者中,身体组成参数与内镜疾病的严重程度相关.
- 骨肌肉质量指数 (SMI) 作为评估CD疾病活动状态的可靠指标.
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