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在移植接受者中治疗晚期皮肤状细胞癌的塞米普利马布
T Van Meerhaeghe1, J F Baurain2, O Bechter3
1Department of Nephrology, Hôpital Erasme - Université Libre de Bruxelles (ULB), Brussels, Belgium.
Frontiers in nephrology
|September 7, 2023
概括
这项研究表明,在移植接受者的晚期皮肤状细胞癌中,塞米普利马布是有效的,整体应答率为42.8%,移植 rejection的风险最小. 这为这些高风险癌症患者提供了新的治疗选择.
科学领域:
- 在瘤学瘤学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
背景情况:
- 移植接受者 (KTR) 由于免疫抑制而面临显著更高的癌症风险.
- 在固体器官移植接受者 (SOTR) 中,晚期皮肤状细胞癌 (cSCC) 是侵略性的,转移和死亡率增加.
- 作为PD-1抑制剂的Cemiplimab已被批准用于高级cSCC,但KTR中的数据有限.
研究的目的:
- 用先进的cSCC.在比利时的KTR中评估塞米普利马布的实际有效性和安全性.
- 为了确定这一特定患者群体的整体反应率 (ORR) 和不良事件发生率.
主要方法:
- 一个回顾性病例系列,七名KTR在2018年至2022年期间接受了先进cSCC的塞米普利马布治疗.
- 患者在之前接受了包括手术,放射治疗和/或化疗在内的治疗后接受了塞米普利马布.
- 收集的数据包括ORR,疾病进展,治疗周期和不良事件,包括移植排斥.
主要成果:
- 在七个KTR中观察到42.8%的整体响应率 (ORR).
- 稳定性疾病在14.3%的人群中被发现,而42.8%的人患有进展性疾病.
- 一名患者经历了活检证明的急性脏异位移植排斥,但获得了完整的瘤反应;在一名患者身上发生了低度的皮肤毒性.
结论:
- 塞米普利马布在KTR中表现出42.8%的ORR,其中先进的cSCC是先前治疗的耐火性.
- 这种治疗在这个队列中显示了低的移植排斥风险 (14.3%) 和良好的整体耐受性.
- 塞米普利马布代表了KTR中高级cSCC的可行的治疗选择,需要进一步调查.
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