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在系统性红血狼中,BAFF系统表达在双负2中,活化原始和活化记忆B细胞在系统性红血狼中
Jhonatan Antonio Álvarez Gómez1, Diana Celeste Salazar-Camarena2, Ilce Valeria Román-Fernández3
1Doctorado en Ciencias en Biología Molecular en Medicina (DCBMM), Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
Frontiers in immunology
|September 7, 2023
概括
BAFF系统参与了系统性红斑狼 (SLE) 的非典型B细胞. 异型B细胞上TACI受体的降低与SLE疾病活性相关,这表明它具有免疫调节作用.
科学领域:
- 免疫学 免疫学 免疫学
- 这是一种自身免疫力.
- B细胞生物学B细胞生物学
背景情况:
- B细胞激活因子 (BAFF) 失调与诸如系统性红斑狼 (SLE) 等自身免疫性疾病有关.
- 表达CD11c的非典型B细胞与SLE病变发生有关.
- 在SLE中这些非典型B细胞中,BAFF系统的作用仍然不清楚.
研究的目的:
- 为了研究BAFF系统组件在SLE患者特定非典型B细胞子集上的表达.
- 探索BAFF系统表达和SLE中的疾病活性之间的关系.
主要方法:
- 流细胞计用于分析45名SLE患者和15名健康受试者 (HS) 的B细胞亚群.
- 在B细胞子集上评估了BAFF及其受体 (BAFF-R,TACI,BCMA) 的表达.
- 与酶相关的免疫吸收试验 (ELISA) 量化了溶性BAFF (sBAFF) 和IL-21水平.
主要成果:
- 在SLE患者中,CXCR5-CD11c+非典型B细胞子集 (DN2,aNAV,SWM,USM) 的频率增加.
- 在SLE B细胞中观察到膜BAFF (mBAFF) 和BCMA受体表达的增加.
- 在SLE中非典型DN2B细胞上TACI表达的降低与较高的IL-21水平和疾病活性增加相关.
结论:
- 在SLE中,BAFF系统在CXCR5-CD11c+非典型B细胞中发挥作用.
- 在非典型的DN2B细胞上减少TACI表达与SLE疾病活性有关,突出了TACI在自身免疫中的潜在免疫调节功能.
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