血清生物标志物预测出血转变和缺血性中风结果在前性队列研究
Elena Costru-Tasnic1, Mihail Gavriliuc1,2, Elena Manole1
1Neurology Department no. 1, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova.
Journal of medicine and life
|September 7, 2023
概括
入院时较低的INR水平可能预测缺血性中风 (IS) 患者的出血转化风险,影响恢复. 需要对特定生物标志物进行进一步的研究,以改善IS结果.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 生物化学 生物化学
背景情况:
- 缺血性中风 (IS) 是全球死亡和残疾的主要原因.
- 预测出血转化 (HT) 等结果对于患者的康复至关重要.
- 确定预后因素可以指导临床管理策略.
研究的目的:
- 调查非特异性实验室数据和血清MMP-2/MMP-9水平的预后作用.
- 在急性缺血性中风 (IS) 患者中预测出血转化 (HT) 风险.
- 评估IS患者的出院预测和3个月的随访状态.
主要方法:
- 150名急性脑梗塞患者的前性队列研究.
- 对入院实验室数据的分析,包括血糖,脂质概况,凝血,炎症标志物,MMP-2和MMP-9等.
- 患有HT的患者 (活跃组) 和没有 (对照组) 的患者之间的比较.
主要成果:
- 活跃组 (有HT) 的心房动 (AF) 过去的发病率明显较高.
- 入院NIHSS和出院/90天的mRS得分在活跃组明显更差.
- 入院时较低的INR值与HT风险 (单变量和多变量分析) 呈反向相关性.
结论:
- 非特定的实验室数据,特别是INR,可以作为IS中HT的预测因素.
- 前庭动史和较差的神经学评分与HT的发展有关.
- 更大的队列研究是必要的,以验证特定的实验室生物标志物来预测IS结果和HT.
关键词:
AF:心房动:心房动是一种心房动.CRP:C-反应性蛋白质 (C-Reactive Protein) 是一种蛋白质.CT:计算机断层扫描 (CT):计算机断层扫描.高密度脂蛋白 (HDL):高密度脂蛋白是一种高密度脂蛋白.HT:出血转变的发生.在INR中,INR就是INR.INR:国际标准化粮食配给IS: 缺血性中风,中风是因为缺血.低密度脂蛋白 (LDL):低密度脂蛋白是一种低密度脂蛋白.在MMP-2中,MMP-2是MMP-2的替代品.在MMP-9中,它是MMP-9的.主要产品:矩阵金属蛋白酶.磁共振成像:磁共振成像的使用方法.美国国家卫生研究院 (NIHSS):国家卫生研究院中风量表.NLR:中性粒细胞与淋巴细胞的比例.TJPs:紧密结合蛋白质:紧密结合蛋白质是一种紧密结合蛋白质.生物标志物 生物标志物血液变化的出血转化缺血性中风预后 缺血性中风预后mRS:修改的兰金级别表.更多相关视频
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