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Updated: Jul 17, 2025

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

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特定于细胞类型的替代多基解促进了非小细胞肺癌进展中的瘤基因表达

Kexin Huang1,2,3, Yun Zhang1, Xiaorui Shi1

  • 1School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710071, China.

Molecular therapy. Nucleic acids
|September 7, 2023
PubMed
概括

破坏的替代多基化 (APA) 通过改变基因表达来影响癌症. 这项研究揭示了非小细胞肺癌 (NSCLC) 中细胞特异性APA事件,确定SPARC作为关键的瘤基因和潜在的治疗标.

关键词:
MT:生物信息学和单细胞RNA测序.替代性的多基化.药物耐药性 耐药性 药物耐药性非小细胞肺癌的肺癌.致癌基因表达的基因表达预后 预后 预后

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