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SHLP6的线粒体多态性m.3017C>T与异热性有关

Sarah V Emser^1,2, Clemens P Spielvogel³, Eva Millesi¹

¹Department of Behavioral and Cognitive Biology, University of Vienna, Vienna, Austria.

Frontiers in physiology

|September 7, 2023

概括

在线粒体衍生 (MDPs) 中的一种特定基因变异 (m.3017C>T) 产生更短的SHLP6蛋白. 这种较短的形式与异热哺乳动物的较低体温有关,这表明在冬眠中发挥了作用.

科学领域:

线粒体遗传学线粒体遗传学
哺乳动物生理学哺乳动物生理学
热调节热调节热调节

背景情况:

异热热调节涉及复杂的代谢调节和亲生存因素.
线粒体衍生 (MDPs) 涉及逆行信号和能量转移在和冬眠期间.

研究的目的:

研究一种特定的线粒体单核酸多态 (SNP),m.3017C>T,在MT-SHLP6基因中的作用.
确定SHLP6大小变异与异热生理学的关联.

主要方法:

分析了人类SHLP6大小的公共质谱数据.
在异热和同热动物中比较了较短的SHLP6异型的频率.
在异热哺乳动物中,与最低体温相关的SHLP6异型存在.
测量了不同生理状态的十三条线地松鼠的棕色脂肪组织中的mt-Shlp6转录水平.

主要成果:

m.3017C>T SNP导致较短的9氨基酸SHLP6异型,与正规的20氨基酸形式不同.
较短的SHLP6异型在异热动物中明显更频繁 (p < 0.001).
较短的SHLP6异型存在与较低的最低体温相关 (p < 0.001).
棕色脂肪组织中的mt-Shlp6转录水平有动态变化,在冬眠前和唤醒期间达到峰值,并在昏迷期间下降.

结论:

由m.3017C>T SNP影响的SHLP6大小变化与哺乳动物异热有关.
研究结果表明,SHLP6异型可能在冬眠和昏迷期间调节体温方面发挥作用.
需要进一步的研究,以阐明SHLP6异型体在温度调节和线粒体逆行信号中的精确机制.

关键词:

在SHLP6中,SHLP6是SHLP6.每天的托尔波尔每日的托尔波尔扩展的脊椎动物线粒体遗传密码冬眠是一种冬眠.微是一种微.线粒体衍生 (MDP) 是一种由线粒体衍生的.微生物基因组学动物动物动物

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