针对性治疗和免疫治疗的发展 - - 如何在未来十年改变非小细胞肺癌的治疗:叙述性综述
Molly S C Li1, Kevin K S Mok2, Tony S K Mok1
1Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong, China.
Annals of translational medicine
|September 7, 2023
概括
向疗法和免疫疗法已经改变了非小细胞肺癌 (NSCLC) 治疗方法,在早期阶段显示出前景,并扩大了晚期疾病的治疗选择. 研究继续解决耐药性机制,以改善患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 免疫学 免疫学 免疫学
背景情况:
- 向治疗和免疫治疗已经彻底改变了非小细胞肺癌 (NSCLC) 治疗.
- 最近的进展表明,在早期NSCLC中有效,减少复发.
- 先进的NSCLC的发展是由基因组测序和理解耐药性的驱动.
研究的目的:
- 为提供针对NSCLC管理的向治疗和免疫疗法的最新发展提供了一个简要的概述.
- 讨论将这些疗法纳入早期NSCLC中的问题.
- 审查转移性NSCLC的向疗法和免疫疗法,包括耐药性机制和新策略.
主要方法:
- 2022年6月在PubMed上进行了全面的文献搜索.
- 搜索术语包括NSCLC,向疗法,免疫疗法,特定基因变异 (EGFR,ALK等). ),免疫检查点 (PD-1,CTLA-4,等等) 的使用. ) 和相关的概念.
- 包括原始论文和评论,以涵盖最新的研究.
主要成果:
- 早期NSCLC受益于新辅助和辅助向治疗和免疫治疗.
- 在转移性NSCLC中可向的改变包括EGFR,ALK,ROS1,BRAF V600E,MET,RET,KRAS G12C,HER2和NRG1.
- 已批准的免疫疗法 (抗PD-L1,抗CTLA4) 和新兴的策略 (抗TIGIT,疫苗,细胞疗法) 被讨论为管理耐药性.
结论:
- 本综述总结了针对NSCLC的向治疗和免疫治疗的最新进展.
- 它强调了可针对性的改变和新的治疗方法的不断扩展的景观.
- 通过这些疗法讨论NSCLC管理的未来方向.
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