狼性病症超越免疫抑制:寻找脏和心脏保护
Enrique Morales1,2,3, Justo Sandino1,2, María Galindo2,3,4
1Department of Nephrology, University Hospital "12 de Octubre", Madrid, Spain.
Frontiers in nephrology
|September 7, 2023
概括
系统性红斑狼 (SLE) 可以导致脏损伤,导致末期脏疾病 (ESKD). 本综述探讨了除了免疫抑制之外的治疗方法,以保护狼性炎 (LN) 的脏和心脏.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 类风湿病学 类风湿病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 脏干扰或狼性炎 (LN) 是系统性红斑狼 (SLE) 的常见并发症,经常进展到末期脏疾病 (ESKD).
- 虽然免疫抑制疗法已为LN建立,但它们在预防慢性病 (CKD) 进展中的作用得到了充分证实.
- 新出现的证据强调了脏保护和心脏保护策略的重要性,以及在LN中蛋白质性CKD患者的免疫抑制.
研究的目的:
- 审查狼性炎 (LN) 中心血管和脏保护的药理选择.
- 探索超越标准免疫抑制和氨酸-血管酶-氨酸系统 (RAAS) 阻断的治疗措施,以改善LN的预后.
- 解决LN管理的背景下,关于特定的脏和心脏保护策略的文献稀缺问题.
主要方法:
- 对心血管和脏保护的药理选择的文献综述.
- 专注于与狼性炎 (LN) 中蛋白尿性慢性病 (CKD) 患者相关的疗法.
- 探索传统的免疫抑制疗法和RAAS封锁之外的治疗方法.
主要成果:
- 免疫抑制疗法是有效的预防慢性病 (CKD) 在狼性炎 (LN).
- 额外的脏和心脏保护措施对于控制心血管风险因素和蛋白尿症至关重要.
- 在LN中,除了RAAS封锁之外的特定保护措施的文献是有限的.
结论:
- 狼性炎 (LN) 的最佳管理需要免疫抑制和有针对性的脏和心脏保护策略的结合.
- 控制心血管风险因素和蛋白尿对于改善LN患者的结局至关重要.
- 需要进一步的研究来阐明各种药理选择在增强LN脏和心血管保护中的作用.
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