在患有晚期胰腺癌的患者中,PD-1阻塞期间的超级进展性疾病
Shiyun Chen1,2, Lu Han1,2, Shiyuan Guo1,2
1Department of Oncology, The First Medical Center of Chinese PLA General Hospital, Beijing, China.
Human vaccines & immunotherapeutics
|September 7, 2023
概括
超渐进性疾病 (HPD),在免疫疗法期间以加速瘤生长为标志,影响胰腺癌 (PC) 患者. 这项研究发现,在接受PD-1抑制剂的PC患者中,HPD发生在9.6%的患者中,与生存率差以及特定的临床因素有关.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 癌症的进展 癌症的进展
背景情况:
- 超渐进性疾病 (HPD) 是一种在免疫治疗期间瘤生长加速的新型模式.
- 在接受免疫治疗的胰腺癌 (PC) 患者中,HPD的发生率和影响在很大程度上是未知的.
研究的目的:
- 在接受编程细胞死亡-1 (PD-1) 抑制剂治疗的晚期胰腺癌患者中调查HPD的发生率,预后和预测因素.
主要方法:
- 从2015年至2020年期间接受PD-1抑制剂治疗的104名晚期PC患者的临床病理数据的回顾性分析.
- 确定HPD病例,并比较HPD和进展性疾病 (PD) 组之间的整体存活率 (OS).
- 分析临床病理因素和基线CA19-9水平作为HPD的潜在预测因素.
主要成果:
- 在10名 (9.6%) 患者中发现了HPD.
- HPD患者的整体存活率明显较低 (平均存活期:5.6个月与3.6个月).
- 高血压病的预测因素包括吸烟,>2个转移部位,肝转移,21天内使用抗生素,低血红蛋白和后期治疗线.
- 高基线CA19-9水平与HPD发展 (p=.024) 和更差的预后相关 (mOS: 16.2 vs 6.1个月).
结论:
- 在接受PD-1抑制剂治疗的胰腺癌患者中,可能会发生超渐进性疾病.
- HPD与特定的临床病理特征有关,预示着预后不佳.
- 基线CA19-9可能成为该患者群体中HPD发展的早期预测因素.
相关概念视频
02:07Tumor Progression
6.4K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.4K
01:24Chronic Pancreatitis I: Introduction
112
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
112