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一种新的眼科海绵的细胞毒性概况

Keon Woo Park1, Ji Woong Chun1, Seong Won Yang1

  • 1Department of Ophthalmology, Chosun University College of Medicine, Gwangju, Republic of Korea.

Cutaneous and ocular toxicology
|September 7, 2023
PubMed
概括

新的眼科海绵Occucell表现出卓越的生物安全性和稳定性. 它保持了高的结膜上皮细胞活力,并显示了与现有产品可比的炎症标志物水平.

关键词:
人类结结膜上皮细胞在体外细胞毒性测试中炎症因素 炎症因素这就是Occucell®.眼科海绵是一种眼科海绵.

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Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...