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Updated: Jul 17, 2025

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
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在T细胞上CD137 mAbs的成本刺激能力取决于复杂的CRD结构,而不是阻断连体受体结合

Xin Jin1, Ling Yi1, Xiaojue Wang1

  • 1Department of Central Laboratory, Beijing Tuberculosis and Thoracic Tumour Research Institute, Beijing Chest Hospital, Capital Medical University, Beijing, China.

European journal of immunology
|September 7, 2023
PubMed
概括

开发了新的CD137抗体,并对它们对T细胞的结合和共刺激作用进行了分析. 不同的结合区域影响T细胞激活,为下一代CD137抗体疗法提供了洞察力.

关键词:
CD137 mAbs 的时间.CD8+ T细胞放大CD8+ T细胞放大CD8+ T细胞放大具有CRD约束力的地区.具有成本刺激能力.造价刺激受体的受体.这就是ICOS ICOS.

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