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晚期肺内和肺外神经内分泌癌的临床特征和预后

Xiao-Yun Chen¹, Ning-Jing Guo², Pei-Lin Guo¹

¹Department of Respiratory and Critical Care Medicine, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, People's Republic of China.

Journal of cancer research and therapeutics

|September 7, 2023

概括

先进的肺内神经内分泌癌 (IPNECs) 显示出比肺外NECs (EPNECs) 更好的生存率. 年龄,肝转移,化疗周期和胸部放射治疗影响NEC的存活率,这表明多学科治疗的好处.

科学领域:

在瘤学瘤学.
肺部病理学肺部病理学
胃肠病学胃肠病学

背景情况:

神经内分泌癌 (NECs) 是一种罕见的恶性瘤,其起源不同.
小细胞肺癌 (SCLC) 是一种主要类型的肺内NEC (IPNEC).
了解晚期NEC的预后因素对于治疗指导至关重要.

研究的目的:

为了比较高级肺内和肺外NEC (EPNEC) 的临床特征和预后.
确定影响NEC患者生存的重要因素.
为SCLC和其他高级NECs的临床管理提供指导.

主要方法:

对123名患有高级IPNEC和EPNEC的患者的临床数据和生存结果的回顾性分析.
检查临床诊断,治疗策略和生存预后.
多变量分析以确定影响整体存活时间 (OS) 的因素.

主要成果:

分析了90个IPNEC (81个SCLC) 和33个EPNEC.
与EPNEC相比,IPNEC的平均整体存活时间 (OS) 显著更长 (P < 0.05).
年龄,肝转移,化疗周期和胸部放射治疗是OS的重要风险因素 (P<0.05).

结论:

肺内NEC的预后比肺外NEC更好.
高龄和肝转移与晚期NECs的预后较差有关.
包括化疗和放射治疗在内的多学科治疗对于改善NEC存活率至关重要.

关键词:

临床特征临床特征神经内分泌癌细胞瘤.小细胞肺癌是小细胞肺癌.生存预后预后生存预后

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