埃及儿童的血溶性尿性综合征:一个单一的中心经历了10年的经验
Hend H Abdelnabi1, Nagy M Abo Elhana1, Ehab A Swilam1
1Department of Pediatrics, Faculty of Medicine, Tanta University Hospitals, Tanta, Egypt.
概括
主要由STEC-HUS引起的埃及儿童的血液溶解尿素综合征 (HUS) 显示出高生存率. 早期透析改善了结果,特别是在中枢神经系统参与的年轻女性.
科学领域:
- 儿科脏病学 儿科脏病学
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
背景情况:
- 血清性尿性综合征 (HUS) 是一种严重的疾病,其特征是微血管病性血清性贫血症,血栓塞缩小症和急性损伤 (AKI).
- 它是全球儿童群体中AKI的主要原因.
- 了解特定地区的HUS模式对于有针对性的干预至关重要.
研究的目的:
- 描述埃及儿童中HUS的临床特征,实验室发现和管理策略.
- 评估HUS病例的结果,包括存活率和长期功能.
- 确定与儿科HUS死亡率相关的风险因素.
主要方法:
- 进行了一项回顾性队列研究,分析了从2009年1月到2019年1月的HUS病例的医院记录.
- 收集的数据包括病史,临床表现,实验室结果,治疗方案和患者结果.
- 检查了68例儿科HUS病例,区分了产生Shiga毒素的大肠杆菌 (STEC) HUS和非典型的HUS.
主要成果:
- 滋果毒素产生的大肠杆菌 (STEC) HUS占病例的96.56%,非典型的HUS占7.53%.
- 常见的表现包括白 (80.88%),腹 (67.65%) 和寡尿 (54.41%).
- 总体生存率为85.29%,死亡率为14.71%. 预测死亡率的因素包括女性性别,5岁以下的年龄,无尿症和中枢神经系统参与.
结论:
- 在这个群体中,STEC-HUS比非典型的HUS更为普遍,结果通常更好.
- 在54.41%的患者中观察到完全康复;然而,25%的患者患有慢性病,5.88%的患者进展到末期病.
- 过早开始透析与死亡率的降低有关,特别是在易受伤害的子组,如年轻女性和中枢神经系统并发症患者.
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