伴侣测试与艾滋病毒艾滋病毒感染的乌干达孕妇的自我测试分布:一个随机试验
Andrew Mujugira1, Agnes Nakyanzi1, Deborah Donnell2
1Infectious Diseases Institute, Makerere University, Kampala, Uganda.
Journal of the International AIDS Society
|September 7, 2023
概括
艾滋病毒自我测试 (HIVST) 的二次分布并没有增加感染艾滋病毒 (PWLHIV) 的孕妇的男性伴侣测试率. 需要额外的策略来改善艾滋病毒检测和与男性伴侣的护理联系.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 全球健康 全球健康
背景情况:
- 艾滋病毒阴性孕妇对艾滋病毒自我检测 (HIVST) 的二次分布增加了男性伴侣的检测.
- 目前尚不清楚这种策略是否对艾滋病毒感染的孕妇 (PWLHIV) 有效.
研究的目的:
- 检查PWLHIV对男性伴侣的HIVST二次传播是否会增加男性伴侣的HIV检测率以及与抗逆转录病毒治疗 (ART) 或口服暴露前预防 (PrEP) 的联系.
主要方法:
- 一个开放标签,个别随机试验在乌干达坎帕拉进行.
- PWLHIV被随机分为2:1分别为他们的男性伴侣或标准护理 (SOC) 的HIVST二次分布,并附有邀请函进行伴侣测试.
- 主要结局包括在临床上对男性伴侣进行测试,并在产后12个月内开始ART或PrEP.
主要成果:
- 共有500名PWLHIV患者被录取,其中236名男性伴侣在诊所进行了测试 (47.2%).
- 在HIVST和SOC手臂之间,男性伴侣HIV检测率 (HR 1.04;95%CI:0.79-1.37) 或ART/PrEP启动时间 (HR 0.96;95%CI:0.69-1.33) 之间没有显著差异.
- 在接受测试的男性伴侣中,88.3%的HIV感染者开始了ART,61.1%的HIV阴性男性开始了PrEP.
结论:
- 与PWLHIV中SOC相比,HIVST的二次分布并没有改善男性伴侣的HIV检测或与ART/PrEP的联系.
- 虽然近一半的男性伴侣进行了测试并与服务联系起来,但需要进一步的战略来增加女性男性伴侣在产前护理中的参与度.
- 在男性伴侣和婴儿中观察到艾滋病毒感染率较低.
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