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Updated: Jul 17, 2025

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在C9ORF72ALS/FTD中通过独特和冗余的AUG启动密码子翻译二重复蛋白

Yoshifumi Sonobe1,2,3, Soojin Lee4,5, Gopinath Krishnan4,5

  • 1University of Chicago Medical Center, Chicago, United States.

eLife
|September 7, 2023
PubMed
概括

科学家们发现,ALS和FTD中的有毒二重复蛋白是使用标准启动信号制造的,这与之前的想法不同. 这一发现为C9orf72相关的神经退行性疾病提供了新的见解.

关键词:
在AUG启动密码子.C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C9ORF72C骨髓缩侧面硬化症 (ALS) 是一种双蛋白重复的蛋白质重复前性痴呆症前性痴呆症遗传学 遗传学 遗传学 是一个基因组学就是基因组学.人类 人类 人类 人类 人类 人类 人类由iPSC衍生的神经元.这里是鼠标鼠标鼠标鼠标鼠标鼠标.神经科学 神经科学

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