在动脉样硬化和血管化发展中的Wnt信号通路和硬化素
Piotr Kocełak1, Monika Puzianowska-Kuźnicka2,3, Magdalena Olszanecka-Glinianowicz4
1Pathophysiology Unit, Department of Pathophysiology, Faculty of Medical Sciences, Medical University of Silesia, Katowice, Poland.
概括
Wnt信号促进动脉样硬化和血管化. 虽然斯克莱洛斯在动物模型中抑制了这些,但由于其来自骨,它可能作为人类血管标记物的用途有限.
科学领域:
- 心血管研究研究心血管研究
- 分子生物学分子生物学
- 病理学 病理学 病理学
背景情况:
- 动脉样硬化包括内皮功能障碍,炎症和血管光滑肌细胞 (VSMC) 增殖.
- 提高Wnt信号的调节是动脉样硬化发展的关键病理机制.
- 斯克莱洛斯在血管疾病中的作用是一个正在积极研究的领域.
研究的目的:
- 在动脉样硬化,血管化,动脉瘤和死亡率中系统地审查关于Wnt信号和硬化素的文献.
- 综合当前关于Wnt信号传递和硬质素在心血管病理学中的双重作用的知识.
- 评估从动物模型到人类疾病的发现的翻译相关性.
主要方法:
- 按照PRISMA指南进行系统审查.
- 在PubMed数据库上进行文献搜索.
- 包括160篇相关的研究论文.
主要成果:
- 升级的Wnt信号驱动动动动脉硬化开始,进展,VSMC扩散和骨质过渡.
- VSMC的骨质转化导致了硬质的表达,可能会抑制Wnt.
- 斯克莱洛斯在小鼠模型中抑制了动脉瘤的形成,但与罗莫苏祖马布的人类数据显示,它对血管参数或动脉瘤发生率没有影响.
结论:
- Wnt通路的激活有助于动脉样硬化,血管重塑和化.
- 斯克莱洛斯在动脉样硬化中的作用是复杂的;它可能是斑块中的保护性反应,但它的血水平受到骨的影响,限制了其作为血管标记物的效用.
- 翻译证据表明,在动物模型中斯克莱洛斯的保护作用可能不直接适用于人类血管疾病的进展或动脉瘤风险.
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