可切除食道状细胞癌患者的新辅助剂卡梅利祖马布和化疗:一个前性的,单臂的,开放的标签研究
Jianping Wang1, Jian Zhang1, Jie Gao1
1Department of Thoracic Surgery, People's Hospital of Yangzhong, China.
概括
新辅助剂camrelizumab加化学疗法在可切除食道状细胞癌 (ESCC) 中显示出高的病理完整反应 (pCR) 率. 这种4周期治疗方案显示出有希望的疗效和安全性,支持对ESCC治疗的进一步研究.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 免疫治疗是一种免疫疗法.
背景情况:
- 食道癌 (EC) 是一个重要的全球健康负担,食道状细胞癌 (ESCC) 是中国的主要亚型.
- 目前可切除ESCC的治疗策略在改善患者的治疗结果方面面临挑战.
研究的目的:
- 评估卡梅利祖马布4周期新辅助疗法的疗效和安全性,与可切除ESCC的化疗相结合.
- 评估病理完整响应 (pCR) 率作为主要终点.
主要方法:
- 35名可切除ESCC的患者接受了新辅助剂卡姆雷利祖马布,纳布-帕克利塔塞尔和卡博普拉丁4个周期.
- 手术是在治疗后4-6周进行的.
- 病理完整响应 (pCR) 率是主要的疗效指标.
主要成果:
- 所有35名患者完成了治疗,并且有资格接受手术.
- 获得了高的R0切除率 (97.1%).
- 病理完整反应 (pCR) 率为51.4%,主要病理反应 (MPR) 率为77.1%.
- 在85.7%的患者中发生瘤退化.
- 年龄和PD-L1表达是PCR的独立预测因素.
- 最常见的不良事件是白血病 (65.7%);3级+中性质减退发生在34.3%的患者中.
- 没有报告手术延迟.
结论:
- 新辅助剂卡姆雷利祖马布加纳布-帕克利塔塞尔和卡博普拉丁四次循环,在可切除ESCC中显示出高PCR率和可接受的安全性.
- 这种疗法需要进一步研究,作为切除ESCC的潜在治疗选择.
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