与COVID-19相关的持续性嗅觉功能障碍相关的促炎性标志物
Sophie S Jang1, Kwang S Pak1, Allyssa Strom2
1Department of Otolaryngology, Head and Neck Surgery, University of California San Diego, La Jolla, California, USA.
International forum of allergy & rhinology
|September 7, 2023
概括
在COVID-19后持续的嗅觉功能障碍可能与嗅觉裂中干扰素 (IFN) 途径细胞因子升高有关. 这项研究确定了粘液样本中的特定生物标志物,预测了COVID-19幸存者的长期气味丧失.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 局部炎症与急性COVID-19嗅觉功能障碍 (OD) 有关.
- 持续的COVID-19 OD (>3个月) 病理生理学和治疗方法仍然不太清楚.
- 嗅觉裂 (OC) 粘液生物标志物被前性地评估为持续性OD的预测因素.
研究的目的:
- 调查嗅觉裂 (OC) 生物标志物作为COVID-19患者持续嗅觉功能障碍 (OD) 的预测因素.
- 为了比较COVID-19幸存者的OC粘液中的炎症和抗病毒生物标志物概况,包括持久性OD和没有持久性OD的幸存者,以及非感染者.
主要方法:
- 一项前性研究,将COVID-19患者的持续性OD (>3个月) 与COVID-19患者没有OD和非感染的对照进行比较.
- 嗅觉裂 (OC) 粘液样本分析了13种抗病毒和炎症生物标志物.
- 使用ANOVA和曼-惠特尼测试比较生物标志物水平;病毒RNA通过RT-PCR (COVID-19 N2原始) 评估.
主要成果:
- 在三个组中发现了干扰素-lambda 1 (IFN-λ1) 和干扰素- (IFN-γ) 表达的显著差异 (分别为p = 0.007和p = 0.006).
- 在COVID-19患者中观察到最高的细胞因子度,特别是IFN-γ,持续存在OD.
- 在COVID-19 OD和没有OD (p = 0.026) 中,IFN-α2水平升高;在IL6或检测到的N2基因表达中没有显著差异.
结论:
- 干扰素 (IFN) 途径细胞因子在持续性嗅觉功能障碍的COVID-19患者的嗅觉微环境中升高.
- 这些发现表明,IFN通路调节失调在COVID-19后长期气味丧失的病理生理学中可能发挥作用.
- OC粘液生物标志物,特别是IFN细胞因子,可能成为持续的COVID-19相关嗅觉功能障碍的预测因素.
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