重量减轻异构干细胞移植后的体重减轻与移植相关死亡率的增加有关
Kayla Madsen1, Katherine Lee1, Shiyi Chen2
1Hans Messner Allogeneic Transplant Program, Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
概括
在全源干细胞移植 (allo-HSCT) 后显著的体重减轻与更高的移植相关死亡率有关. 早期干预和监测对于改善alo-HSCT患者体重减轻的结果至关重要.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 移植医学 移植医学 移植医学
背景情况:
- 同源干细胞移植 (allo-HSCT) 患者面临营养不良和体重减轻的风险.
- 由于胃肠道毒性,失调和心理影响而导致口服摄入量受损,有助于这些问题.
研究的目的:
- 研究接受allo-HSCT.的成年患者减肥的发生率和结果.
- 确定显著的WL与生存,复发和移植相关死亡率 (TRM) 之间的关联.
主要方法:
- 追溯对264名成年患者的回顾,这些患者在allo-HSCT后实现了无复发生存期.
- 移植后3个月和6个月减肥百分比的分析.
- 基于WL值的总生存率 (OS),无复发生存率 (RFS) 和TRM的比较.
主要成果:
- 45.9%的患者在3个月后出现≥10%的WL,在6个月后56.6%的患者出现≥10%的WL.
- 在 ≥10% WL 和 <10% WL 的患者之间,在 2 年的 OS 或 RFS 中没有观察到显著的差异.
- 在3个月和6个月内,患有≥10%WL的患者显示出显著更高的2年TRM (35.4%对16.9%和22%对8%).
结论:
- 虽然总体存活率和无复发存活率没有受到体重减轻的显著影响,但与移植相关的死亡率显著更高.
- 涉及跨学科团队的多方面的方法对于管理减肥后合HSCT以减少TRM至关重要.
- 密切监测体重和早期干预对于改善患者结果至关重要.
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