相关实验视频
Updated: Jul 17, 2025

08:40
Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
7.2K
肠道微生物群对缺乏引起的肠肝炎的贡献
Guodong Wang1, Zhihui Jiang1, Yuwei Song1
1Henan Joint International Research Laboratory of Veterinary Biologics Research and Application, Anyang Institute of Technology, Anyang, Henan, China.
BioFactors (Oxford, England)
|September 7, 2023
概括
缺乏会破坏肠道细菌,减少肠道紧密的接口,增加透性. 这可能会通过TLR4途径导致肝损伤,但Se或L. reuteri可以帮助.
科学领域:
- 微生物学 微生物学
- 肝病学 肝病学是一种肝病学.
- 营养科学 营养科学
背景情况:
- 肠-肝轴功能障碍在缺乏症后是鲜为人知的.
- 对肠道和肝脏健康的作用需要进一步调查.
研究的目的:
- 研究缺乏对小鼠肠道微生物群和肝损伤的影响.
- 探索涉及紧接口和TLR信号的潜在机制.
主要方法:
- 小鼠受到缺乏症的影响.
- 评估了血清,LPS,肝脏生物标志物,并进行了组织学分析.
- 通过16S rRNA测序评估了肠道透性,TJ和TLR通路的基因/蛋白质表达,并通过16S rRNA测序评估了状菌群.
主要成果:
- 缺乏障碍了谷氨过氧化酶的活性,破坏了肠道菌群 (减少Lactobacillus reuteri),并减少了紧结的表达.
- 观察到肠道透性增加,肝损伤和LPS水平.
- 补充剂,便微生物种移植或L. reuteri可以逆转这些效应并调节TLR信号.
结论:
- 缺乏会破坏肠道微生物群和屏障功能,增加透性和LPS转移.
- 升高的LPS可能会通过TLR4信号通路诱导炎症性肝损伤.
- 恢复水平或特定的微生物群可以减轻这些有害影响.
相关概念视频
Sulfur Assimilation
38
Sulfur is an essential element in biological systems, contributing to synthesizing key biomolecules, including amino acids such as cysteine and methionine, and cofactors such as coenzyme A and biotin. Microorganisms primarily assimilate sulfur as sulfate (SO₄²⁻) from the environment, which must undergo a series of biochemical transformations before it can be incorporated into cellular components. As sulfate is highly oxidized, it must undergo assimilatory sulfate reduction to...
38
Bacterial Flora of the Large Intestine
508
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
508
Irritable Bowel Syndrome I: Introduction
311
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
311
Anatomy of the Intestines
72.3K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
72.3K

