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Updated: Jul 17, 2025

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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p53功能获取突变通过BRD4-依赖的CSF-1表达诱导转移

Gizem Efe1,2, Karen J Dunbar1, Kensuke Sugiura1

  • 1Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York.

Cancer discovery
|September 7, 2023
PubMed
概括

一个涉及p53-R172H依赖的BRD4-CSF-1轴的新途径促进食道状细胞癌 (ESCC) 肺转移. 抑制这一轴可以减少瘤的入侵和转移,为ESCC提供新的治疗策略.

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