在严重的α-1抗素缺乏症患者中,COVID-19疫苗的安全性和反应性
Oliver J McElvaney1,2,3,4, Brian Cleary1, Daniel D Fraughen1,2
1Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.
患有α-1抗素缺乏症 (AATD) 的患者能像其他群体一样耐受COVID-19疫苗. 联合COVID-19和流感疫苗对于AATD患者是安全的,大多数不良事件是轻微的.
科学领域:
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 阿尔法-1抗素缺乏症 (AATD) 与炎症和自身免疫有关.
- 对于严重的AATD患者,缺乏COVID-19疫苗安全数据.
- 在AATD中同时使用COVID-19和流感疫苗的可行性尚不清楚.
研究的目的:
- 评估COVID-19疫苗在严重AATD患者中的安全性和耐受性.
- 评估在AATD中联合使用COVID-19和流感疫苗的可行性.
- 为了比较AATD患者和对照组之间的不良事件概况.
主要方法:
- 对接受ChAdOx1 nCoV-19疫苗的170名Pi*ZZ基因型AATD患者进行前性研究.
- 在接种第一剂和第二剂疫苗后对不良事件 (AE) 的监测.
- 与Pi*MM COPD和Pi*MM非肺病控制组进行比较.
- 随访mRNA增强剂疫苗和流感疫苗的同时使用.
主要成果:
- 与对照组相比,AATD患者没有增加AE.
- 大多数AE是轻微的和自我限制的;年轻女性的风险更高.
- 患有肺气,肝病或接受增强疗法的患者没有增加AE风险.
- 在最初的疫苗系列后,AE发病率下降.
- 在同一天同时使用COVID-19和流感疫苗是安全的.
结论:
- 严重的AATD患者不会面临来自COVID-19疫苗的更高风险.
- 同时使用COVID-19助推剂和流感疫苗是安全的,并且在AATD中耐受良好.
- 这项研究为疫苗接种弱势群体提供了关键的安全数据.
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