肺癌遗传风险和吸烟的种族差异:两个前性队列研究
Meng Zhu1,2, Jun Lv3,4,5, Yanqian Huang1,2
1Department of Epidemiology, International Joint Research Center on Environment and Human Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
International journal of epidemiology
|September 7, 2023
概括
遗传因素的种族差异影响了欧洲和东亚人口之间的肺癌风险. 多基因风险评分揭示了不同的吸烟相互作用,突出了针对种族特定的肺癌预防策略的需要.
科学领域:
- 人口遗传学 人口遗传学
- 癌症流行病学癌症流行病学
- 遗传风险因素 遗传风险因素
背景情况:
- 欧洲和东亚人口之间肺癌相对风险的差异,特别是关于吸烟的差异,尚未完全理解.
- 遗传背景被假设在吸烟相关的肺癌风险中所观察到的这些差异中起作用.
研究的目的:
- 调查种族差异对遗传因素对吸烟相关肺癌风险的影响.
- 为了比较中国和欧洲队伍之间的遗传风险,吸烟相互作用和绝对风险降低.
主要方法:
- 在中国和欧洲人群中构建了针对肺癌的民族特异性多基因风险评分 (PRS).
- 在中国Kadoorie生物银行 (CKB) 和英国生物银行 (UKB) 中,比较了PRS,吸烟状况及其对肺癌风险的相互作用.
- 在5年期间评估绝对风险降低.
主要成果:
- 特定种族的PRS显示出差异,特别是与吸烟相关的遗传局部.
- PRS一直与肺癌风险相关,在UKB吸烟者中相关性更强.
- 在UKB中发现了遗传风险和吸烟之间的显著相互作用,但在CKB中没有发现.
- 在CKB非吸烟者中观察到更高的绝对肺癌风险.
- 在比较大量吸烟者与非吸烟者时,在UKB中发现了更大的绝对风险降低,特别是在高遗传风险人群中.
结论:
- 遗传因素的种族差异有助于吸烟相关的肺癌风险差异.
- 东亚非吸烟者中肺癌的高发病率与这些种族遗传差异有关.
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