在帕金森病中异常高阶网络相互作用视觉幻觉
Joshua B Tan1, Eli J Müller1,2, Isabella F Orlando1
1Brain and Mind Centre, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney 2050, Australia.
帕金森病中的视觉幻觉与大脑网络通信的改变有关. 先进的分析揭示了感官和高级网络之间的集成增加,这表明在感知障碍中存在共同的脆弱性.
科学领域:
- 神经科学是一个神经科学.
- 系统神经科学 系统神经科学
- 计算神经科学是一种神经科学.
背景情况:
- 视觉幻觉在帕金森病 (PD) 中很常见.
- 功能障碍的大脑网络通信,特别是感官和高级网络之间的通信,与PD幻觉有关.
- 确切的功能性大脑变化仍然不清楚.
研究的目的:
- 用先进的维度减小技术来描述与PD视觉幻觉相关的功能层次的改变.
- 研究大脑网络之间的功能整合在视觉幻觉病理生理学中的作用.
主要方法:
- 应用非线性维度减小技术:扩散图嵌入和t分布式随机邻近嵌入 (t-SNE).
- 分析了77名PD患者 (31名有幻觉,46名没有) 和19名健康对照的休息状态功能性MRI数据.
- 使用传统的功能连接分析进行比较.
主要成果:
- 在患有幻觉的PD患者中发现了单模态-异模态梯度的压缩,这表明感官和更高阶网络之间的功能整合增加.
- 在幻觉组中观察到视觉和默认模式网络之间的连接性增加.
- t-SNE分析揭示了在传统分析中不明显的明显前额叶变化.
结论:
- 结果表明,更高阶区域可能过度影响PD幻觉中的感官处理.
- 异常的大脑组织在PD的幻觉表型中得到证实.
- 感官感知系统的等级差异化减少可能是感知障碍的神经精神疾病的跨诊断漏洞.
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