患有部发育性发育不良的患者表现出更高的数字比率 (2D:4D)
Oguz Kaya1, Nevzat Gonder2, Dilsad Arisoy Demir3
1Department of Orthopaedics and Traumatology, Elazığ Fethi Sekin City Hospital, Elazığ 23280, Turkey.
Early human development
|September 7, 2023
概括
第二到第四位数的比率 (2D:4D) 是产前激素暴露的标志物,在男性和女性中与部发育性发育不良 (DDH) 有显著的关联. 这一发现表明,早期的荷尔蒙平衡与部发育之间存在联系. 关键词:2D:4D比例,部发育性形,DDH,产前荷尔蒙暴露.
科学领域:
- 整形外科和运动医学
- 发育生物学 发展生物学
- 内分泌学 在内分泌学.
背景情况:
- 部发育性形 (DDH) 是一种部疾病,在女性中患病率较高.
- 产前性类固醇暴露与DDH病变产生有关,但其直接标记物仍未得到充分研究.
- 第二到第四位数比率 (2D:4D) 作为产前雄激素与雌激素平衡的验证生物标志物.
研究的目的:
- 研究2D:4D比率与部发育性形 (DDH) 之间的关联.
- 为了确定是否产前性类固醇暴露,以2D:4D比率表示,与DDH易感性相关.
主要方法:
- 一项涉及250名DDH患者和200名健康对照者的病例控制研究.
- 用数字标尺测量了数字长度; 2D:4D比率计算了两只手.
- 统计分析包括曼·惠特尼U测试和双向ANOVA,以比较群体并评估性别/副作用.
主要成果:
- 与对照组相比,DDH患者的右和左2D:4D比率显著更高,不论性别.
- 这些2D:4D比率的差异在DDH的男性和女性中都是显著的.
- 发育不良的方面没有影响观察到的2D:4D比率和DDH之间的关联.
结论:
- 在两性中,较高的2D:4D比率与部发育性形 (DDH) 有显著的关联.
- 这表明,由2D:4D比率反映的变化的子宫内雌激素/平衡可能在DDH病因学中起作用.
- 2D:4D比为评估与产前荷尔蒙影响相关的DDH风险提供了一个潜在的非侵入性生物标志物.
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