一个与疾病相关的注意力UNet框架,用于逐步和稳定地识别轻度认知障碍
Zhehao Zhang1, Linlin Gao2, Pengyuan Li3
1First Affiliated Hospital of Ningbo University, Ningbo, 315020, China; Faculty of Electrical Engineering and Computer Science, Ningbo University, Ningbo 315210, China.
Computers in biology and medicine
|September 7, 2023
概括
这项研究引入了一个新的AI框架,DAUF,使用脑部扫描更好地识别渐进和稳定的轻度认知障碍. 这一进步有助于更早地诊断阿尔茨海默病,并改善患者的护理.
科学领域:
- 神经成像是一种神经成像.
- 人工智能的人工智能
- 医学诊断 医学诊断 医学诊断
背景情况:
- 早期诊断阿尔茨海默病 (AD) 亚型,特别是渐进性轻度认知障碍 (pMCI) 和稳定的轻度认知障碍 (sMCI),对于患者的生活质量至关重要.
- 使用结构磁共振成像 (sMRI) 的卷积神经网络 (CNN) 模型对阿尔茨海默病的识别有希望,但在从关键大脑区域提取多个规模的特征方面存在困难.
研究的目的:
- 开发一个先进的深度学习框架,以准确识别pMCI和sMCI.
- 加强与疾病相关的多层次脑组织的分析,这些脑组织通常被现有的CNN方法忽视.
主要方法:
- 提出一个端到端的框架,称为疾病相关的注意力UNet框架 (DAUF).
- 整合一个双重疾病相关的注意模块 (D2AM),以捕捉特征和注意地图之间的互补特征,以及编码-解码阶段.
- 使用一种新的树结构特征融合分类器 (TFFC) 来有效地融合多尺度特征和分类.
主要成果:
- 提出的DAUF框架在识别pMCI和sMCI受试者方面表现出卓越的表现.
- 实验证实了D 2 AM和TFFC组件在提高分类准确性的有效性.
结论:
- DAUF提供了一个强大的工具来区分pMCI和sMCI,改进了现有的基于CNN的方法.
- 该框架能够有效地从sMRI数据中提取和融合多尺度特征,这对早期阿尔茨海默病诊断具有重大潜力.
更多相关视频
07:26Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking
Published on: September 26, 2019
7.9K
07:42Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients
Published on: December 16, 2022
3.0K
相关概念视频
01:26Alzheimer's Disease: Overview
517
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
517
01:30Dementia
139
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
139
01:22Alzheimer's Disease: Treatment
212
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
212