控制位置:当失败被认为是理所当然时,大脑是如何放弃的
Joseph M Villarin1, Christoph Kellendonk2
1Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032, USA.
Neuron
|September 7, 2023
概括
小鼠不再试图逃避无法控制的压力,并变得不活跃. 研究人员发现,一个大脑电路,即轨道前皮层与轨道前皮层相连的地方,是这种适应性应激反应的关键.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 压力研究 压力研究
背景情况:
- 慢性压力和无法控制的环境会导致行为变化.
- 暴露在不可避免的压力下的小鼠从积极的逃避转变为被动的不活动.
- 了解这种行为转换的基础的神经机制至关重要.
研究的目的:
- 识别在慢性压力下适应性行为转向不活动时所涉及的神经回路.
- 阐明特定大脑区域和神经元通路在应对压力机制中的作用.
主要方法:
- 使用了受到慢性压力范式的小鼠模型.
- 采用神经解剖学追踪技术来绘制神经投影的地图.
- 使用光遗传学或化学遗传学研究特定神经元群体的功能 (详细信息未提供摘要).
主要成果:
- 鉴定出源于coeruleus位置的noradrenergic投射.
- 证明这些投影的目标是轨道前皮层的GABAergic投影神经元.
- 发现这些特定的神经连接能够调解从逃避行为转向不活动的转换.
结论:
- 轨道前皮层回路的状位置在适应性行为反应中发挥着关键作用,以应对无法控制的压力.
- 这种神经通路促进了过渡到不活动作为一个应对策略,当逃脱是不可能的.
- 研究结果提供了对应激弹性和适应不良行为的神经生物学的见解.
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