抗微生物保护的银纳米集群的绿色合成,具有受调节的抗菌行为
Jingrui Du1, Yujie Cong1, Xiaoyu Wang1
1State Key Laboratory for Advanced Metals and Materials, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, P. R. China.
ACS applied bio materials
|September 7, 2023
概括
与抗微生物结合的超小银纳米集群提供强大,持久的抗菌作用. 这种绿色合成方法增强了细菌膜的透和反应性氧物种的产生,以获得广泛的疗效.
科学领域:
- 纳米材料科学 科学 纳米材料科学
- 生物化学 生物化学
- 微生物学 微生物学
背景情况:
- 基于银的材料显示出作为抗菌剂的前景.
- 银纳米材料的抗菌活性受到成分和特性的影响.
- 开发有效和安全的抗菌剂至关重要.
研究的目的:
- 使用抗微生物合成超小的银纳米集群.
- 研究这些新型纳米集群的抗菌机制.
- 评估它们的稳定性,细胞毒性和长期疗效.
主要方法:
- 使用抗微生物的银纳米集群的绿色合成.
- 纳米集群特性和与细菌膜的相互作用的表征.
- 评估反应性氧物种的产生和氧化应激.
- 对各种细菌的抗菌活性的评估.
主要成果:
- 带正电荷的配体促进了对细菌的静电吸引.
- 超小的纳米集群通过疏水性协会穿透细菌膜.
- 增强的反应性氧物种产生导致细菌死亡.
- 纳米集群表现出良好的稳定性,低细胞毒性和长期抗菌活性.
- 观察到协同作用的抗菌作用.
结论:
- 与抗微生物结合的银纳米集群作为协同抗菌剂.
- 这种方法可以实现快速,持久和广泛的抗菌作用.
- 与细菌的生物相互作用得到了有效的调节,以提高疗效.
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