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在跨性别个体的性别确认激素治疗期间,囊素C基EGFR的变化

Sarah A van Eeghen^1,2, Chantal M Wiepjes^1,2, Guy T'Sjoen³

¹Center of Expertise on Gender Dysphoria, Department of Internal Medicine, Amsterdam University Medical Centers, Location VU Medical Center, Amsterdam, The Netherlands.

Clinical journal of the American Society of Nephrology : CJASN

|September 7, 2023

概括

性别肯定激素疗法影响功能. 雌激素治疗增加了跨性别女性估计的淋巴球过率 (eGFR),而治疗降低了跨性别男性的eGFR,基于囊素C水平.

科学领域:

内分泌学在内分泌学.
腎臟病學 (nephrology) 是一種醫學專業.
跨性别者健康跨性别者健康

背景情况:

男人通常比女性更快地经历功能下降,可能是由于性激素.
关于性别肯定激素治疗 (GAHT) 对功能的影响的研究有限.
血清肌素,一个常见的功能标志物,受到身体组成的影响,这使得在GAHT期间的监测变得复杂.

研究的目的:

为了研究性激素和功能之间的关系,在经过GAHT的跨性别个体中.
为了评估血清肌素和血清囊素C (一种更稳定的过标志物) 在GAHT1年的变化.
为了评估GAHT对估计的膜过率 (eGFR) 的影响,使用cystatin C.

主要方法:

分析了来自欧洲调查性别不一致性网络研究的260名跨性别女性和285名跨性别男性的队列.
在GAHT开始前和12个月后测量了血清肌素和血清囊素C水平.
基于cystatin C的eGFR是使用全年龄谱方程计算的.

主要成果:

接受雌激醇和抗雄激素治疗的跨性别女性表现出囊素C的减少,相当于eGFR增加7毫升/分钟/1.73米2.
接受丸激素治疗的跨性别男性表现出囊C的增加,相当于eGFR的6毫升/分钟/1.73米2下降.
变性女性的肌素水平下降,变性男性的肌素水平增加,基于肌素的eGFR显示出显著的变化.

结论:

性别确认激素治疗显著改变跨性别者的功能标志物.
雌激醇和抗雄激素治疗与变性女性的功能改善 (EGFR增加) 有关.
丸激素治疗与跨性别男性的功能下降 (eGFR下降) 有关.

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