佛洛口服颗粒的配方,表征,药理动力学和抗氧化活性
Radni D Deshpande1, Devanshi S Shah1, Sharda Gurram1
1Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai, India.
International journal of pharmaceutics
|September 7, 2023
概括
这项研究使用Gelucire® 44/14和固体载体开发了口服佛罗素 (PHL) 颗粒. 这种新型配方显著改善了PHL.
科学领域:
- 药理学 药理学是指药理学的学科.
- 药物输送系统 药物输送系统
- 自然产品 化学 化学
背景情况:
- 罗 (PHL) 是一种二酸盐类黄类物质,由于溶解性和吸收性较低,其口服生物利用性较差.
- 提高黄胺溶解度通常涉及将它们纳入聚合物或脂质矩阵以改善溶解和吸收.
研究的目的:
- 开发稳定,口服可用的具有改善药理动力学特性的素颗粒.
- 为了研究Gelucire® 44/14的使用以及用于罗素配方的固体载体.
- 为了评估在配制的佛洛素颗粒中抗氧化物质的保留.
主要方法:
- 罗素通过融溶解在Gelucire® 44/14中溶解.
- 一种粘性半固体融被吸附在使用SeDeM-SLA专家系统选择的固体载体上,以创建自由流动的颗粒.
- 评估了颗粒的特性,稳定性,药理动力学特性和抗氧化活性.
主要成果:
- 成功开发出自由流动的口服佛罗素颗粒,增强溶解性和溶解性.
- 配制的颗粒显示出良好的稳定性和有利的药理动力学特征.
- 选择的固体载体有效地保留了罗的固有抗氧化特性.
结论:
- 使用Gelucire® 44/14的融技术和固体载体吸附是一种可行的方法,用于制备口服佛洛素颗粒.
- 开发的配方克服了与洛相关的生物可用性挑战.
- 这项研究证实了这种方法在提供具有改善治疗功效的黄类药物方面的潜力.
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